ncRNA name | Sirna-027 |
ncRNA Category | siRNA |
Disease name | choroidal neovascularization (CNV) |
Species | Mus musculus |
Tissues/Cell_line | retinas and choroidal flat mounts |
Methods | BrdU labeling, siRNA injection, qRT-PCR, luciferase reporter assay, ELISA |
Expression pattern | associated |
Functional description | We used siRNA directed against vegfr1 mRNA to investigate the role of VEGFR1 in ocular neovascularization. After evaluating many siRNAs, Sirna-027 was identified. In a CNV model, intravitreous or periocular injections of Sirna-027 resulted in significant reductions in the area of NV. In mice with ischemic retinopathy, intravitreous injection of Sirna-027 reduced retinal NV by 32%. |
PubMed ID | 16195704 |
Year | 2006 |
Title | Suppression of ocular neovascularization with siRNA targeting VEGF receptor 1. |
Drug-related ncRNA | NO |
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